BSRT Graduate School
Ivo Panov
| Nationality: | Bulgaria |
| Organisation: | Charité - Universitätsmedizin Berlin |
| Institute: | Institute of Medical Immunology |
| Department: | Transplantation Tolerance |
| Address: | Augustenburger Platz 1 13353 Berlin |
| Campus: | Charité Campus Virchow-Klinikum Südstraße 2 |
| Phone: | +49 (0)30 450524335 |
| E-Mail: | This e-mail address is being protected from spambots. You need JavaScript enabled to view it |
| Track: | Biology Track |
| At BSRT since: | 01.05.2009 |
| Graduation: | 13.04.2015 |
| PhD Mentoring Committee: | |
| Title of PhD project: | Transcriptional control of tolerance associated gene TCAIM in dendritic cell |
| CV: | Since 12/2009 PhD Student at Institute of Medical Immunology, Charité - Universitätsmedizin Berlin, Germany. 09/2008 to 12/2008 Internship at BioGenes GmbH, Berlin, Germany. Generation of Monoclonal Antibodies 10/2006 to 09/2008 M.Sc. in Molecular Bioengineering at Biotechnology Center TU Dresden, Germany. 09/2001 to 09/2005 B.Sc. in Biotechnology at University of Food Technology Plovdiv, Bulgaria. |
| Project Abstract: | An ultimate goal in transplantation medicine and treatment of autoimmune diseases is development of short term therapies for safe induction and prolonged maintenance of tolerance. Current immunosuppressive treatments lead to life-long dependency and undesired side effects. Therefore, novel cell therapies including adoptive transfer of donor or recipient derived dendritic cells have become an attractive option in transplantation. However, stable tolerogenic phenotype in dendritic cells is rarely achieved in vivo. In my project, I aim to circumvent this limitation by reinforcing tolerance associated gene-1 (TOAG-1) expression in dendritic cells to render them tolerogenic. Initially, putative factors in TOAG-1 transcriptional control will be identified and main pathways involved in promoter regulation will be revealed. Further on, post-transcriptional silencing by microRNAs will be investigated and sequential contrary antagomir-based inhibition will be designed. By interfering in TOAG-1 transcriptional and post-transcriptional regulation, the current project is proposing a mechanism for tolerogenic dendritic cell reprogramming and their application for induction of antigen-specific tolerance in vitro and in vivo. |
| Presentations: | Talk Panov I, Schlickeiser S, Vogel S, Schumann J, Berberich-Sibelt F, Sawitzki B. cAMP/CREB dependent transcriptional control of Tolerance Associated Gene-1 in bone marrow derived dendritic cells inhibits maturation and renders them tolerogenic. Congress of the Europen Society for Organ Transplantation, Glasgow, United Kingdom, 4-7 September 2011 Poster Panov I, Schlickeiser S, Vogel S, Berberich-Sibelt F, Sawitzki B. Generation and reprogramming of tolerogenic dendritic cells by transcriptional control of TOAG-1. Young Researchers in Life Sciences Congress, Paris, France, 9-11 May 2011 |
| Thesis (BSc, MSc): | Master Thesis: Reprogramming of the immune system using bifunctional antibodies: Developing of bi-specific diabodies for redirecting foamy viruses to tumor cells |
