We would like to cordially invite you to attend the BCRT Lecture Series 2015
“Linked in regeneration” wants to join young and senior scientists from Berlin to come together and discuss with internationally renowned guest speakers how to advance research into regenerative medicine and its translation into the clinics. The BCRT lecture series is organized and hosted by young postdocs of the graduate school of the BCRT.

Speaker: Josef Penninger

(Institute of Molecular Biotechnology - Vienna)

Host: Malte Spielmann (BSRT Clinical Scientist)

This lecture takes place at 16:00 as a double lecture within the topic Dissecting Disease mechanisms using models of tissue regeneration and biomineralisation. The other lecture by Prof. Marc McKee is at 17:00.

Rankl - from bone metabolism to

breast cancer

Gene targeting and mutagenesis using stem cell technologies are powerful tools to elucidate essential functions of genes in normal physiology and in the pathogenesis of disease. Using gene-targeted mice, Professor Penninger and his team try to genetically dissect disease mechanisms and establish new models of tissue regeneration. Further achievements include pioneering insights into the molecular basis of osteoporosis and breast cancer, as well as the study of metastatic spread. His group has also developed the first haploid embryonic stem cells for functional genetics. Using these approaches, Josef Penninger tries to establish basic principles of development and disease pathogenesis.

Click here for profile of Josef Penninger

Four interesting publications

Osteoclast differentiation factor RANKL controls development of progestin-driven mammary cancer.

[Click here for PubMed]

Central control of fever and female body temperature by RANKL/RANK.

[Click here for PubMed]

OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis

[Click here for PubMed]

The osteoclast differentiation factor osteoprotegerin-ligand is essential for mammary gland development

[Click here for PubMed]

Venue:
Auditorium 0.0045

Berlin Brandenburg Center for Regenerative Therapies (BCRT)

Charité | Campus Virchow Klinikum

Föhrer Str. 15 | 13353 Berlin

More Information: www.b-crt.de/das-zentrum/veranstaltungen/bcrt-lecture-series/

Kindly supported by the "Verein der Freunde und Förderer der Berliner Charité e.V."