Andreas Kurtz Profile Page
| Organisation: | Charité |
| Institute: | Institute for Medical Immunology |
| Address: | Charitéplatz 1 10117 Berlin |
| Campus: | Mitte |
| E-Mail: | This e-mail address is being protected from spam bots, you need JavaScript enabled to view it |
| Field: | Stem Cell Applications |
| Track(s): | Bio;Med |
| CV: | 2003-2006 Head, Stem Cell Research Group and Head Licensing Office for Embryonic Stem Cell Research, Robert Koch-Institute, Berlin 2003-2006 Adjunct Associate Professor for Neurosurgery, Harvard University, Cambridge, USA 2000-2003 Assistant Professor for Neurosurgery at Harvard Medical School and Associate Geneticist at Massachusetts General Hospital, Cambridge/Boston, USA 1997-2000 CEO of Genomed Diagnostic GmbH and Ingene GmbH 1995-2000 Assistant Professor for Pharmacology and Neurosurgery, Georgetown University, Washington DC, USA 1993-1995 Guest Researcher at NIH/NIMH, Bethesda, USA 1991-1992 Postdoctoral Fellow, NIH/NIMH, Bethesda, USA 1990-1992 Postdoctoral Fellow at Ludwig Institute Uppsala/Sweden and NIH/USA 1990 PhD 1985-1990 Staff Scientist, Central Institute for Molecular Biology Berlin-Buch 1980-1985 Diploma in Biology/Genetics Martin Luther University Halle |
| Research Interests: | The main purpose of our research is the development and improvement of cell therapies. We are working with two cell systems: (1) T-cells to repair and support derailed immune systems by adoptive therapy. (2) The application of stem cells in various degenerative diseases. In both cases cells are recognized as the major therapeutic agent, which needs to be thoroughly characterized and if necessary functionally enhanced for therapeutic efficacy. The scope of the work thus includes improving the manufacturing modes for these cells, finding tools for the molecular and functional characterization of the cells and the studying the interaction of the cell therapeutics with the host organism in models and in patients. Specifically we are using T-cell s for the treatment of organ and cell transplantation induced adverse reactions, such as EBV or CMV virus replications. In addition, we are applying mesenchymal stem cells in therapeutic applications for neurodegeneration and cardiac disease. The selection, expansion, testing and monitoring of the cells are a major focus of the work. |
| Publications: | Kurtz A, Guhr A, Friedgen K, Loser P (2006) Current State of Human Embryonic Stem Cell Research: An Overview of Cell Lines and their Usage in Experimental Work. Stem Cells: in press Mashour GA, Drissel SN, Frahm S, Farassati F, Martuza RL, Mautner VF, Kindler-Röhrborn A, Kurtz A (2005) Differential Modulation of Malignant Peripheral Nerve Sheath Tumor Growth by Omega-3 and Omega-6 Fatty Acids. Oncogene 24: 2367-2374 Kurtz A, Lueth M, Kluwe L, Zhang T, Foster R, Mautner V-F, Hartmann M, Tan D-J, Martuza RL, Friedrich RE, Hernaiz Driever P, Wong LJ (2004) Somatic mitochondrial DNA mutations in Neurofibromatosis type 1-associated tumors. Molecular Cancer Research 2: 433-441 Kurtz A, Aigner A, Cabal RH, Butler RE, Hood DE, Sessions RB, Czubayko F and Wellstein A (2004) Differential regulation of an FGF-binding protein during skin carcinogenesis and wound healing. Neoplasia 6: 595-602 Mashour A, Ratner N, Khan GA, Wang H-L, Martuza RL, Kurtz A (2001) The angiogenic factor midkine is aberrantly expressed in NF1-deficient Schwann cells and is a mitogen for neurofiroma- derived cells. Oncogene 20: 97-105 Wang H-L, Kurtz A (2000) Breast Cancer Growth Inhibition by delivery of the MDGI-derived peptide P108. Oncogene 19: 2455-2460 Liu X, Webster deFH, Mashour GA, Kurtz A (1998) Basic FGF and FGF-receptor 1 are expressed in microglia during experimental autoimmune encephalomyelitis: temporally distinct expression of midkine and pleiotrophin. Glia. 24: 390-397 Kurtz A, Wang HL, Derwisch N, Harris V, Wellstein A (1996) Expression of a FGF- binding protein is associated with epithelial development and skin carcinogenesis. Oncogene 14: 2671-2681 Kurtz A, Zimmer A, Schnuetgen F, Spener F, Muller T (1994) The expression pattern of a novel gene encoding brain fatty acid binding protein correlates with neuronal and glial development. Development 120: 2637- 2649 Kurtz A, Vogel F, Funa K, Heldin HC, Grosse R (1990) Developmental regulation of mammary derived growth inhibitor in bovine mammary tissue. J Cell Biology 110: 1779-1789 |
